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Clonidine overdose: a review.

C S Conner, A S Watanabe

American Journal of Hospital Pharmacy

|July 1, 1979

Summary

This summary is machine-generated.

Clonidine overdose can cause serious symptoms like CNS depression and bradycardia. Treatment involves gastric lavage, activated charcoal, and supportive care for hypotension and bradycardia.

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Area of Science:

Pharmacology
Toxicology
Emergency Medicine

Background:

Clonidine is an antihypertensive drug acting centrally.
Therapeutic doses are generally safe and effective.
Overdosage presents significant clinical challenges.

Purpose of the Study:

Review clonidine pharmacology and pharmacokinetics.
Detail symptoms of acute clonidine overdosage.
Outline current treatment strategies for clonidine toxicity.

Main Methods:

Literature review of clonidine pharmacology.
Analysis of clinical presentation in clonidine overdosage.
Synthesis of established treatment protocols for overdose management.

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Main Results:

Clonidine overdose symptoms include CNS depression, bradycardia, hypotension, miosis, hypotonia, and respiratory depression.
Gastric lavage and activated charcoal reduce absorption.
Intravenous fluids, dopamine, and atropine sulfate are key treatments.

Conclusions:

Prompt management is crucial for clonidine overdose.
Supportive care and specific antidotes are effective.
Avoidance of certain agents like tolazoline is advised unless refractory.