Anticancer Drug Extraction from Plasma Samples Using Three-Dimensional Polyoxometalate-Based Supramolecular...

Area of Science:

• Inorganic-organic hybrid materials synthesis and characterization.
• Polyoxometalate chemistry and supramolecular assembly.
• Analytical chemistry and separation science.

Background:

• Development of novel materials for analytical applications is crucial.
• Efficient extraction and detection of anticancer drugs in biological matrices are challenging.
• Polyoxometalate-based frameworks offer unique properties for adsorption and separation.

Purpose of the Study:

• To synthesize and characterize novel inorganic-organic hybrid materials.
• To evaluate the efficacy of these materials as sorbents for dispersive micro-solid-phase extraction (D-μSPE).
• To develop and validate an analytical method for quantifying anticancer drugs in human plasma.

Main Methods:

• Hydrothermal synthesis of four inorganic-organic hybrid materials containing Keggin units and lanthanoids.
• Structural characterization using X-ray diffraction and other techniques.
• Application of the synthesized materials in D-μSPE for doxorubicin and epirubicin extraction from human plasma, followed by HPLC-FLD analysis.

Main Results:

• Four novel hybrid materials with 3D network structures were successfully synthesized.
• The materials demonstrated effective performance as sorbents in D-μSPE.
• The developed HPLC-FLD method showed good linearity (0.8-500 ng mL⁻¹ and 1.0-500 ng mL⁻¹), low limits of detection (0.2-0.3 ng mL⁻¹), and high precision (3.5-4.3%) for the target anticancer drugs.

Conclusions:

• The synthesized polyoxometalate-based hybrid materials are promising sorbents for D-μSPE.
• The D-μSPE-HPLC-FLD method provides a sensitive and reliable approach for analyzing anticancer drugs in human plasma.
• This study contributes to the development of advanced materials for pharmaceutical analysis and clinical monitoring.