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Published on: February 20, 2019
Cytoplasmic Polyadenylation Element Binding Protein 1 and Atherosclerosis: Prospective Target and New Insights
1Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, School of Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Insights
Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) regulates gene expression and is linked to atherosclerosis. This review explores CPEB1's role in cardiovascular disease prevention and treatment.
Area of Science:
- Molecular Biology
- Cardiovascular Research
- Gene Regulation
Background:
- Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) is an RNA-binding protein crucial for gene expression.
- CPEB1 regulates translation by binding to the 3'-untranslated regions of messenger RNA (mRNA).
- Emerging evidence highlights CPEB1's significant involvement in the pathological mechanisms underlying atherosclerosis.
Purpose of the Study:
- To review the physiological functions of CPEB1.
- To discuss recent research on CPEB1's role in atherosclerosis.
- To explore CPEB1's potential in preventing and treating atherosclerotic heart disease.
Main Methods:
- Literature review of existing research on CPEB1 and atherosclerosis.
- Analysis of CPEB1's regulatory mechanisms in gene expression.
- Synthesis of findings related to pathological processes in atherosclerosis regulated by CPEB1.
Main Results:
- CPEB1 regulates key pathological processes in atherosclerosis, including inflammation, lipid metabolism, endothelial dysfunction, angiogenesis, oxidative stress, cellular senescence, apoptosis, and insulin resistance.
- CPEB1's function evolves, impacting both healthy physiology and disease states.
- CPEB1 is implicated in the development and progression of atherosclerotic cardiovascular disease.
Conclusions:
- CPEB1 is a critical regulator implicated in multiple facets of atherosclerosis.
- Understanding CPEB1's role offers potential therapeutic targets for atherosclerotic heart disease.
- Further research into CPEB1's mechanisms may lead to novel prevention and treatment strategies.
Abstract:
The ribonucleic acid (RNA)-binding protein Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1), a key member of the CPEB family, is essential in controlling gene expression involved in both healthy physiological and pathological processes. CPEB1 can bind to the 3'- untranslated regions (UTR) of substrate messenger ribonucleic acid (mRNA) and regulate its translation. There is increasing evidence that CPEB1 is closely related to the pathological basis of atherosclerosis. According to recent investigations, many pathological processes, including inflammation, lipid metabolism, endothelial dysfunction, angiogenesis, oxidative stress, cellular senescence, apoptosis, and insulin resistance, are regulated by CPEB1. This review considers the prevention and treatment of atherosclerotic heart disease in relation to the evolution of the physiological function of CPEB1, recent research breakthroughs, and the potential participation of CPEB1 in atherosclerosis.
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