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Updated: Jun 23, 2026

Growth Assays to Assess Polyglutamine Toxicity in Yeast

Growth Assays to Assess Polyglutamine Toxicity in Yeast

Published on: March 5, 2012

Viral-based animal models in polyglutamine disorders.

Carina Henriques^1,2,3,4, Miguel M Lopes^1,2,3,5, Ana C Silva^1,2,3,5

¹Center for Neuroscience and Cell Biology (CNC), Gene and Stem Cell Therapies for the Brain Group, University of Coimbra, 3004-504 Coimbra, Portugal.

Brain : a Journal of Neurology

|January 29, 2024

Summary

Viral vectors offer a flexible and efficient method for creating animal models of polyglutamine disorders. This approach complements transgenic models, aiding research into these incurable neurodegenerative conditions.

Keywords:

adeno-associated vectors brain lentiviral vectors neurodegenerative disorders non-human primates rodents

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Growth Assays to Assess Polyglutamine Toxicity in Yeast

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Published on: March 5, 2012

Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster

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Published on: March 12, 2018

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Published on: September 21, 2021

Area of Science:

Neuroscience
Genetics
Molecular Biology

Background:

Polyglutamine disorders are incurable neurodegenerative diseases.
Caused by expanded cytosine-adenine-guanine (CAG) trinucleotide repeats.
Transgenic animal models are crucial but have limitations.

Conclusions:

Viral vectors are a valuable tool for polyglutamine disorder research.
Essential considerations for model development are discussed.
A comprehensive review of current viral-based models is presented.