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A meta-analysis of melanoma risk in idiopathic inflammatory myopathy patients
Rui Luo1, Dan Xia2, Siyang Yu2
1General medicine department, The first People's hospital of Longquanyi District Chengdu, Sichuan, China. luorui2083@qq.com.
Background:
Idiopathic inflammatory myopathy (IIM) is a group of chronic acquired autoimmune diseases. The association between IIM and malignancies has been observed for decades. No meta-analysis has been conducted to summarize the relationship between IIM and melanoma. Herein, we specifically wanted to investigate whether IIM is associated with a higher incidence of melanoma.
Methods:
We searched both Chinese and English databases (CNKI, VIP, Wanfang, PubMed, Embase, Web of Science) for studies on IIM related to melanoma published up to October 2023. Two independent authors reviewed all literature to identify studies according to predefined selection criteria. Fixed effects models were applied to pool the risk. Publication bias was also evaluated and sensitivity analysis performed.
Results:
A total of 1660 articles were initially identified but only four cohort studies met the criteria. Thus, 4239 IIM patients were followed up. The pooled overall risk ratio/hazard ratio was 3.08 (95% confidence interval [CI] 0.79-5.37) and the standardized incidence ratio was 6.30 (95% CI 1.59-11.02).
Conclusion:
The present meta-analysis suggests that IIM patients are at a significantly higher risk of developing melanoma.
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