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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
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Macrophages and angiogenesis in human lymphomas
Domenico Ribatti1, Roberto Tamma2, Tiziana Annese2,3
1Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Bari, Italy. domenico.ribatti@uniba.it.
Clinical and Experimental Medicine
|January 29, 2024
Summary
Tumor-associated macrophages (TAMs), primarily the M2 subtype, fuel lymphoma progression by promoting angiogenesis and immune suppression. Targeting these TAMs and their pro-angiogenic functions offers a potential therapeutic strategy for lymphoma treatment.
Area of Science:
- Oncology
- Immunology
- Cancer Biology
Background:
- Chronic inflammation is linked to cancer development, involving immune cells, angiogenesis, and tumor progression.
- Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment in hematologic malignancies.
- TAMs, predominantly M2-polarized, drive tumor growth, immune evasion, and poor prognosis.
Purpose of the Study:
- To define the role of TAMs in lymphoma.
- To elucidate the relationship between TAMs and angiogenesis in lymphoma patients.
- To review published data and present emerging findings on TAMs and angiogenesis in lymphoma.
Main Methods:
- Review of existing literature on TAMs and angiogenesis in lymphoma.
- Analysis of data from the authors' own studies.
- Discussion of anti-angiogenic therapeutic approaches.
Main Results:
- M2 TAMs are the predominant subtype in tumors, promoting angiogenesis, lymphangiogenesis, and immune suppression.
- TAMs contribute to increased tumor cell proliferation, drug resistance, and adverse clinical outcomes in lymphoma.
- The relationship between TAMs and angiogenesis is a critical factor in lymphoma progression.
Conclusions:
- TAMs play a significant role in lymphoma pathogenesis through their pro-angiogenic and immunosuppressive functions.
- Understanding the TAM-angiogenesis axis is crucial for developing novel lymphoma treatments.
- Anti-angiogenic strategies targeting TAMs hold promise for improving lymphoma therapy.
