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Related Concept Videos

Teratogenicity01:07

Teratogenicity

2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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Updated: Jul 4, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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The Future of the Teratogenicity Testing.

Muhsin Aydin1, Banu Guven Ezer2, Eyyup Rencuzogullari3

  • 1Department of Biology, Science and Letters Faculty, Adiyaman University, Adiyaman, Turkey.

Methods in Molecular Biology (Clifton, N.J.)
|January 29, 2024
PubMed
Summary

Teratogenicity testing faces challenges with current in vivo and in vitro methods. Developing faster, reliable, and validated alternative tests is crucial for understanding congenital diseases.

Keywords:
Future of teratologyTeratogenicity testsTeratology

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Area of Science:

  • Toxicology
  • Developmental Biology
  • Reproductive Health

Background:

  • Teratogenicity testing is vital for assessing risks of congenital diseases.
  • Existing in vivo and in vitro methods have limitations, including ethical concerns and incomplete metabolic profiling.
  • Over half of congenital diseases remain unexplained despite advanced diagnostics.

Conclusions:

  • There is a critical need for faster, reliable, and cost-effective teratogenicity tests.
  • Validated in vitro methods like the embryonic stem cell test (EST), micro mass test (MM), and whole embryo culture (WEC) show promise.
  • Advancing and implementing these alternative methods is essential for accurate teratogenicity assessment and understanding congenital diseases.