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Biometry-Based Technique for Determining the Anterior Scleral Thickness: Validation Using Optical Coherence
Satish Kumar Gupta1, Rohit Dhakal1,2, Pavan Kumar Verkicharla1,2
1Myopia Research Lab, Prof. Brien Holden Eye Research Centre, Brien Holden Institute of Optometry and Vision Sciences, L V Prasad Eye Institute, Hyderabad, India.
Translational Vision Science & Technology
|January 29, 2024
Summary
A noncontact optical biometer can accurately estimate anterior scleral thickness (AST) using optical coherence tomography (OCT) landmarks. This finding expands the utility of biometers in myopia research and clinical practice.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Optometry
Background:
- Anterior scleral thickness (AST) is implicated in myopia development.
- Optical biometers are widely used in eye care for axial length measurements.
- A need exists to validate alternative methods for AST assessment.
Purpose of the Study:
- To apply and validate a biometry-based technique for estimating AST.
- To utilize optical coherence tomography (OCT) landmarks for AST measurement.
- To assess the correlation between biometer-derived and OCT-derived AST.
Main Methods:
- Anterior scleral thickness (AST) was measured in 62 participants using swept-source OCT and a noncontact optical biometer.
- Measurements were taken across four meridians at a standardized distance from the limbus.
- A-scan peaks from the biometer were correlated with OCT landmarks to determine tissue thickness.
Main Results:
- Biometer and OCT measurements of AST showed strong correlation (overall r = 0.82).
- Mean AST differences between instruments were minimal (3 ± 2.8 µm).
- AST varied by meridian, being thickest inferiorly and thinnest superiorly, with good biometer repeatability.
Conclusions:
- Noncontact optical biometers can accurately estimate anterior scleral thickness (AST) by referencing OCT landmarks.
- This technique enhances the application of optical biometers in myopia research and clinical practice.
