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    This study introduces a novel method for discovering causal relationships from observational data, even with unmeasured confounding. The approach leverages the principle of independent mechanisms to identify true causal effects in complex systems.

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    Area of Science:

    • Causal Inference
    • Machine Learning
    • Statistical Modeling

    Background:

    • Unmeasured confounding poses a significant challenge to causal discovery from observational data.
    • Constraint-based methods struggle when unobserved variables widely affect observed ones, leading to unidentifiable causal effects.
    • Existing methods often fail in high-dimensional settings with widespread unobserved confounding.

    Purpose of the Study:

    • To develop a method for discovering causal relationships in the presence of unmeasured confounding.
    • To leverage the principle of independent mechanisms to disentangle spurious and causal effects.
    • To propose a scalable algorithm for causal discovery in complex systems.

    Main Methods:

    • Utilizing the principle of independent mechanisms to identify statistical footprints of unobserved confounding.
    • Applying a sparse linear Gaussian directed acyclic graph (DAG) model for causal structure recovery.
    • Developing an adjusted score-based causal discovery algorithm compatible with general-purpose solvers.

    Main Results:

    • Demonstrated that unobserved confounding leaves a detectable statistical footprint under the principle of independent mechanisms.
    • Showed that a sparse linear Gaussian DAG can be approximately recovered from observational data.
    • The proposed algorithm scales to high-dimensional problems and is robust to deviations from model assumptions.

    Conclusions:

    • Causal discovery is feasible even with widespread unmeasured confounding by exploiting the principle of independent mechanisms.
    • The developed algorithm offers a scalable and robust solution for identifying causal structures in complex observational datasets.
    • The methodology shows potential for extension to nonlinear structural models, broadening its applicability.