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Related Concept Videos

Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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Insulin: Dosing Regimen and Adverse Effects01:16

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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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SBAR II: Application of SBAR01:14

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SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
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Oral Hypoglycemic Agents: Glinides01:06

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Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
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Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
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Pseudohypoglycemia: A Pitfall in Everyday Practice.

Eric W Robbins1, Taro Minami2, Kamran Manzoor2

  • 1Division of Internal Medicine, Rhode Island Hospital / Brown University, Providence, RI.

Rhode Island Medical Journal (2013)
|January 29, 2024
PubMed
Summary
This summary is machine-generated.

Pseudohypoglycemia, or falsely low blood glucose readings, is a common issue in hospitals. Clinicians must know how to identify and test for this laboratory artifact to ensure accurate patient care.

Keywords:
clinical testingdiabetesfalse positiveshypoglycemiapseudohypoglycemia

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Endocrinology

Background:

  • Hypoglycemia is frequently observed in hospitalized patients.
  • Laboratory test results can sometimes inaccurately indicate low blood glucose levels.
  • This discrepancy is known as pseudohypoglycemia.

Purpose of the Study:

  • To raise awareness among clinicians about the phenomenon of pseudohypoglycemia.
  • To provide guidance on identifying situations where pseudohypoglycemia may occur.
  • To outline appropriate testing strategies for confirming pseudohypoglycemia.

Main Methods:

  • Review of clinical literature on pseudohypoglycemia.
  • Analysis of common causes and laboratory interferences.
  • Discussion of diagnostic approaches and confirmatory tests.

Main Results:

  • Pseudohypoglycemia can result from various factors, including certain collection tube additives or rare blood cell abnormalities.
  • Specific laboratory tests can differentiate true hypoglycemia from pseudohypoglycemia.
  • Early recognition prevents unnecessary clinical interventions for falsely low glucose levels.

Conclusions:

  • Pseudohypoglycemia is a critical diagnostic consideration in clinical practice.
  • Awareness and appropriate testing are essential for accurate diagnosis and patient management.
  • Understanding pseudohypoglycemia improves the reliability of blood glucose monitoring in healthcare settings.