Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Respiratory and acid-base parameters during salicylic intoxication in dogs.

P R Silva, A Fonseca-Costa, W A Zin

    Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
    |January 1, 1986
    PubMed
    Summary

    Salicylate poisoning causes significant hyperventilation by acting centrally on the brain, not primarily through increased body temperature. This central action is key to understanding respiratory changes in salicylism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Symptom presentation of childbirth-related post-traumatic stress in 31 countries: the INTERSECT study.

    Journal of affective disorders·2026
    Same author

    Smoking After a Cancer Diagnosis in Brazil: Divergent Perceptions and Awareness of Tobacco-Related Harms Among Patients and Caregivers.

    Cancer medicine·2026
    Same author

    Do white matter microstructural alterations associated with childhood maltreatment explain psychopathology in early adulthood?-a longitudinal neuroimaging study.

    European child & adolescent psychiatry·2025
    Same author

    Antenatal paternal adjustment and paternal attitudes after infertility treatment.

    Human reproduction (Oxford, England)·2017
    Same author

    In vitro estimation of pressure drop across tracheal tubes during high-frequency percussive ventilation.

    Physiological measurement·2014
    Same author

    Association between respiratory mechanics and autonomic function in morbid obesity.

    Revista portuguesa de pneumologia·2013

    Area of Science:

    • Toxicology
    • Neuroscience
    • Respiratory Physiology

    Background:

    • Acute salicylism, often due to aspirin overdose, can lead to severe respiratory disturbances.
    • Hyperventilation and respiratory alkalosis are common but their underlying mechanisms require clarification.

    Purpose of the Study:

    • To investigate the mechanism of hyperventilation and respiratory alkalosis in acute salicylism.
    • To determine the role of central nervous system salicylate concentration versus systemic effects.

    Main Methods:

    • Administered sodium salicylate to anesthetized dogs.
    • Monitored respiratory parameters (ventilation, tidal volume) and arterial blood gases.
    • Measured salicylate levels in cerebrospinal fluid (CSF) and plasma.
    • Assessed changes in body temperature.

    Related Experiment Videos

    Main Results:

    • Minute ventilation increased over 600% of baseline, peaking 60-100 minutes post-infusion.
    • CSF salicylate levels correlated strongly (r=0.974) with increased ventilation.
    • Hyperventilation preceded significant hyperthermia, indicating temperature was not the primary driver.

    Conclusions:

    • Central nervous system action of salicylate is the primary driver of hyperventilation in acute salicylism.
    • Systemic effects, such as uncoupling of oxidative phosphorylation, play a minor role compared to central effects.