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Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
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CT synthesis from MR images using frequency attention conditional generative adversarial network.

Kexin Wei1, Weipeng Kong1, Liheng Liu2

  • 1Shandong Key Laboratory of Medical Physics and Image Processing, Shandong Institute of Industrial Technology for Health Sciences and Precision Medicine, School of Physics and Electronics, Shandong Normal University, Jinan, China.

Computers in Biology and Medicine
|January 29, 2024
PubMed
Summary

This study introduces a new deep learning model, FACGAN, to create synthetic CT images for MR-only radiotherapy. FACGAN generates clearer, higher-quality synthetic CT images with improved high-frequency details.

Keywords:
Attention mechanismDeep learningGenerative adversarial networksMRSynthetic CT

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Area of Science:

  • Medical Imaging
  • Radiotherapy Physics
  • Artificial Intelligence in Medicine

Background:

  • Magnetic resonance (MR) image-guided radiotherapy requires synthetic computed tomography (sCT) images for treatment planning.
  • Convolutional neural networks (CNNs) show promise for sCT generation but often produce blurred images with insufficient high-frequency details.

Purpose of the Study:

  • To develop an advanced deep learning model for generating high-quality sCT images from MR data.
  • To improve the accuracy and clarity of sCT images for effective radiotherapy planning.

Main Methods:

  • Proposed a frequency attention conditional generative adversarial network (FACGAN) incorporating a frequency cycle generative model (FCGM) and a residual frequency channel attention (RFCA) module.
  • Introduced high-frequency loss (HFL) and cycle consistency high-frequency loss (CHFL) for model optimization.
  • Validated the model on pelvic and brain datasets, comparing it with existing deep learning methods.

Main Results:

  • FACGAN successfully generated higher-quality sCT images compared to state-of-the-art models.
  • The proposed model preserved and enhanced clearer, richer high-frequency texture information in the synthetic images.
  • Improved inter-mapping between MR and CT data, extracting more detailed tissue structures.

Conclusions:

  • FACGAN effectively addresses the limitations of CNN-based sCT generation, producing superior image quality.
  • The enhanced high-frequency detail generation is crucial for accurate radiotherapy planning in MR-only workflows.
  • This approach holds significant potential for advancing MR-only radiotherapy techniques.