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A phase II study of ibrutinib in combination with ixazomib in patients with Waldenström macroglobulinaemia

Ricardo D Parrondo1, Navnita Dutta2, Betsy R LaPlant3

  • 1Mayo Clinic Cancer Center, Jacksonville, Florida, USA.

British Journal of Haematology
|January 29, 2024
PubMed

This phase II study evaluated time-limited (24 cycles) treatment with ibrutinib and ixazomib in newly diagnosed (NDWM; n = 9) and relapsed/refractory (RRWM; n = 12) Waldenström macroglobulinaemia (WM). The overall response rate (ORR) was 76.2% (n = 16) in 21 evaluable patients with no patient achieving a complete response (CR). The median duration of treatment was 15.6 months, and after a median follow-up time of 25.7 months, the median progression-free survival (PFS) was 22.9 months. While the primary end-point was not met (CR rate at any time) and 28.5% discontinued treatment due to toxicity, ibrutinib plus ixazomib led to a clinically meaningful ORR and PFS. Combined Bruton's tyrosine kinase (BTK) and proteasome inhibition merits further evaluation in WM.

Keywords:
Waldenstrom's macroglobulinaemiaclinical trialsnon Hodgkin's lymphoma

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