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Updated: Jul 4, 2025
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Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
Published on: October 11, 2017
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Movement-Related Modulation in Mouse Auditory Cortex Is Widespread Yet Locally Diverse
Karin Morandell1, Audrey Yin1, Rodrigo Triana Del Rio1
1Center for Neural Science, New York University, New York, New York 10012.
Summary
Movement significantly impacts auditory cortex neurons in mice. This study found that locomotion
Area of Science:
- Neuroscience
- Auditory Processing
- Motor Control
Background:
- Auditory cortex neurons exhibit behavioral modulation, including response suppression and enhancement during movement.
- The mouse auditory cortex contains multiple fields with specialized sound processing and connections to motor centers.
- Previous research suggests heterogeneity in movement-related modulation at the single-cell level within the auditory cortex.
Purpose of the Study:
- To investigate whether movement-related modulation differs across distinct auditory cortical fields in male mice.
- To understand the contribution of field-specific modulation to the overall heterogeneity of neural responses during movement.
- To characterize how locomotion affects sound processing in different auditory cortical areas.
Main Methods:
- Utilized wide-field calcium imaging to delineate auditory cortical fields.
- Employed cellular-resolution two-photon calcium imaging to monitor layer 2/3 excitatory neuron activity.
- Recorded neural responses to pure tones, chirps, and amplitude-modulated white noise during rest and locomotion on a treadmill.
Main Results:
- Individual neurons typically responded to a single sound category, maintaining tuning across conditions.
- Locomotion modulated sound-evoked responses at the single-cell level, causing both suppression and enhancement.
- The net effect of locomotion on auditory responses was conserved across different auditory cortical fields.
- Movement-related modulation reflected running speed and non-locomotor movements, with similar patterns observed across all fields.
Conclusions:
- Movement-related modulation is a widespread phenomenon across the mouse auditory cortex.
- Despite field-specific differences in sound processing, the impact of locomotion on auditory responses is largely conserved.
- Auditory cortex activity is complexly influenced by various behavioral states beyond simple locomotion.
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