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Published on: December 2, 2016
A Meta-Analysis for Postoperative Alternations of Aortic Coarctation
Yu Bao1, Zhao Wang2, Sibi Shan3
1Department of Cardiovascular Surgery, Yan'an Affiliated Hospital of Kunming Medical University, 65000 Kunming, Yunnan, China; Key Laboratory of Cardiovascular Disease of Yunnan Province, 65000 Kunming, Yunnan, China; Yunnan Province Clinical Medicine Center for Cardiovascular Disease, 65000 Kunming, Yunnan, China. 18087265026@163.com.
Objective:
To investigate postoperative vascular changes of patients with coarctation of the aorta (CoA).
Methods:
Literature review of updated articles was performed in June 2023 through the following databases: PubMed, Web of Science, EMBASE, Crohrane Library, CNKI and Wanfang database. All the case-control studies regarding the postoperative changes of vascular structure and function in patients with CoA were analyzed.
Results:
A total of 596 articles from the above databases were initially identified, with 10 articles being selected for meta-analysis. The analysis showed that weighted mean difference (WMD) of carotid intima-media thickness (cIMT) was 0.07 (95% CI = 0.01~0.13, p < 0.01) and WMD of flow mediated dilation (FMD) was -4.36 (95% CI = -7.49~-1.24, p < 0.01), respectively. The postoperative cIMT of CoA patients was higher than that of the control group, but the postoperative FMD was lower than that of the control group.
Conclusions:
The operation on CoA patients ameliorates anatomical deformity in the vascular structures. However, intima-media thickening and endothelial malfunction remain as the key postoperative issues.
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