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Mortality in patients with adrenal insufficiency: a protocol for a systematic review and meta-analysis

Francesca Allosso1, Konstantinos Dalakas2,3, Ragnhildur Bergthorsdottir2,3

  • 1Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

BMJ Open
|January 29, 2024
PubMed
Abstract

Insights

This systematic review examines long-term mortality in patients with adrenal insufficiency (AI). It synthesizes evidence on survival rates and causes of death, including cardiovascular and infectious diseases, to inform patient care.

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Public Health

Background:

  • Adrenal insufficiency (AI) is a rare endocrine disorder affecting glucocorticoid secretion.
  • Current AI treatment focuses on optimized glucocorticoid replacement and circadian rhythms.
  • The impact of modern AI treatments on patient survival remains unclear.

Purpose of the Study:

  • To systematically review and synthesize evidence on long-term mortality in patients with adrenal insufficiency.
  • To investigate specific causes of death, particularly cardiovascular and infectious diseases, in the AI population.

Main Methods:

  • Systematic literature search of Medline, Embase, Cochrane, and Web of Science databases until May 2023.
  • Inclusion of observational studies with a reference population, assessed using the Newcastle-Ottawa scale.
  • Narrative data integration and meta-analysis for homogeneous studies, adhering to PRISMA guidelines.

Main Results:

  • This section is to be populated upon study completion.

Conclusions:

  • This systematic review will provide valuable insights into mortality patterns in adrenal insufficiency.
  • Findings will aid healthcare providers in optimizing patient management and care strategies.
  • The study aims to be the first comprehensive assessment of mortality and its causes in AI patients.
Keywords:
Adrenal disordersCARDIOLOGYGeneral endocrinologyMortalityPituitary disorders

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