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Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review

Juan Francisco Palma-Ordóñez1, Ana María Moreno-Fernández2, Jorge Antolín Ramírez-Tejero3

  • 1Unidad de Gestión Clínica de Salud Mental, Hospital Universitario Virgen de Valme, Seville, Spain.

International Journal of Rheumatic Diseases
|January 30, 2024
PubMed

Insights

Fibromyalgia (FM) is a widespread chronic pain condition. Research highlights gut microbiota imbalances and their influence on the gut-brain axis as key factors in FM

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Immunology

Background:

  • Fibromyalgia (FM) affects 4.7% globally, causing widespread pain and diverse symptoms.
  • Its multifactorial origin complicates diagnosis and treatment.
  • Emerging research links the gut microbiota to FM pathogenesis.

Approach:

  • Systematic review of recent studies on FM etiopathogenesis.
  • Focus on the gut-brain axis and microbiota-host interactions.
  • Analysis of dysbiosis and altered bacterial metabolites in FM patients.

Key Points:

  • FM patients exhibit intestinal microbiota imbalances (dysbiosis).
  • Altered levels of short-chain fatty acids and lipopolysaccharides are observed.
  • Microbiota influences neurotransmitter pathways (serotonin, glutamate, GABA).

Conclusions:

  • The gut microbiota plays a significant role in fibromyalgia development.
  • Dysbiosis and altered microbial metabolites contribute to FM symptoms via the gut-brain axis.
  • Understanding these mechanisms offers potential therapeutic targets for fibromyalgia.
Keywords:
etiopathogenesisfibromyalgiagut microbiotagut-brain axismetabolome

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