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Autophagy, Ferroptosis, Apoptosis and Pyroptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease

Shuangshuang Zhao1, Yan Guo1, Xunzhe Yin2

  • 1School of Clinical Medicine, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China.

Frontiers in Bioscience (Landmark Edition)
|January 30, 2024
PubMed

Insights

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects 25% globally. Targeting programmed cell death (PCD) pathways offers a promising therapeutic strategy for MASLD prevention and treatment.

Area of Science:

  • Hepatology
  • Cell Biology
  • Metabolic Diseases

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition with increasing global incidence.
  • MASLD is characterized by liver inflammation, oxidative stress, insulin resistance, and lipid metabolism disruptions.
  • MASLD is a leading cause of cirrhosis and hepatocellular carcinoma.

Purpose of the Study:

  • To review the role of programmed cell death (PCD) in MASLD pathogenesis.
  • To explore the potential of modulating PCD pathways as a therapeutic strategy for MASLD.

Main Methods:

  • Comprehensive literature review on MASLD and PCD pathways.
  • Analysis of the involvement of autophagy, ferroptosis, apoptosis, and pyroptosis in MASLD.
  • Identification of key effector molecules in PCD pathways relevant to MASLD.

Main Results:

  • Programmed cell death (PCD) is a critical regulator in MASLD progression, influencing liver inflammation, fibrosis, and malignant transformation.
  • Multiple PCD pathways, including autophagy, ferroptosis, apoptosis, and pyroptosis, are activated during MASLD.
  • Specific effector molecules within these PCD pathways are potential therapeutic targets.

Conclusions:

  • Targeting programmed cell death (PCD) pathways presents a viable therapeutic approach for MASLD.
  • Modulation of PCD may prevent or treat MASLD and its complications.
  • Further research into PCD effectors could lead to novel MASLD treatments.
Keywords:
apoptosisautophagyferroptosismetabolic dysfunction-associated steatotic liver diseasepyroptosis

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