Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain dopamine receptor levels elevated in canine narcolepsy.

S S Bowersox, T S Kilduff, K F Faull

    Brain Research
    |January 27, 1987
    PubMed
    Summary

    Dogs with narcolepsy show higher dopamine D2 receptor concentrations in key brain areas like the nucleus accumbens. This suggests impaired dopamine release may contribute to canine narcolepsy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.

    Molecular psychiatry·2012
    Same author

    Defining intact protein primary structures from saliva: a step toward the human proteome project.

    Analytical chemistry·2012
    Same author

    Mouse brain concentrations of 3-methoxytyramine and normetanephrine: a comparison of methods of sacrifice.

    Neurochemistry international·2010
    Same author

    Further characterization of sleep-active neuronal nitric oxide synthase neurons in the mouse brain.

    Neuroscience·2010
    Same author

    Gene expression in the rat brain during prostaglandin D2 and adenosinergically-induced sleep.

    Journal of neurochemistry·2008
    Same author

    Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep.

    Neuroscience·2006

    Area of Science:

    • Neuroscience
    • Veterinary Medicine
    • Pharmacology

    Background:

    • Narcolepsy is a neurological disorder affecting sleep-wake cycles.
    • Genetically transmitted narcolepsy in dogs offers a model for human narcolepsy research.
    • Dopamine pathways are implicated in sleep regulation and motor control.

    Purpose of the Study:

    • To investigate dopamine D2 receptor concentrations in dogs with genetically transmitted narcolepsy.
    • To explore the role of the mesolimbic system in canine narcolepsy.
    • To identify potential neurochemical alterations associated with narcolepsy in dogs.

    Main Methods:

    • Scatchard analysis was used to quantify dopamine D2 receptors.
    • [3H]spiperone was employed as the radioligand for receptor binding assays.

    Related Experiment Videos

  • Dopamine and its metabolites were measured in discrete brain regions.

    • Main Results:

    • Significantly higher dopamine D2 receptor densities were observed in the nucleus accumbens, rostral caudate, and amygdala of narcoleptic dogs compared to controls.
    • In the amygdala, elevated dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were found in narcoleptic dogs.
    • No significant changes in 3-methoxytyramine (3-MT) or homovanillic acid (HVA) concentrations were detected in the amygdala.

    Conclusions:

    • The findings indicate involvement of the mesolimbic dopamine system in canine narcolepsy.
    • Impaired dopamine release is a potential etiologic factor in genetically transmitted canine narcolepsy.
    • Dopamine D2 receptor abnormalities may contribute to the pathophysiology of narcolepsy.