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Published on: September 29, 2019
The Association Between S100A12 Protein and C-Reactive Protein with Malignant Ventricular Arrhythmias Following Acute
Lei Song1, Ying-Min Lu1, Jin-Chun Zhang1
1Department of Cardiology, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, 202150, People's Republic of China.
Insights
S100A12 protein and C-reactive protein (CRP) are independent risk factors for malignant ventricular arrhythmias (MVA) in elderly patients after acute myocardial infarction (AMI). Their combined use offers higher diagnostic accuracy for MVA prediction.
Area of Science:
- Cardiology
- Biomarkers
- Geriatric Medicine
Background:
- Acute myocardial infarction (AMI) poses significant risks for elderly patients, including life-threatening malignant ventricular arrhythmias (MVA).
- Identifying reliable biomarkers for MVA prediction post-AMI is crucial for timely intervention in the elderly population.
Purpose of the Study:
- To investigate the association of S100A12 protein and C-reactive protein (CRP) with the onset of MVA after AMI in elderly individuals.
- To evaluate the diagnostic and predictive value of S100A12 and CRP, both individually and in combination, for MVA in this demographic.
Main Methods:
- A cohort of 159 elderly AMI patients was studied.
- Serum levels of S100A12 (ELISA) and CRP (biochemical analyzer) were measured.
- Multivariate logistic regression and ROC curve analysis were employed to identify risk factors and assess predictive accuracy.
Main Results:
- S100A12 protein and CRP were identified as independent risk factors for MVA post-AMI in the elderly (p < 0.05).
- The area under the ROC curve (AUC) for S100A12 was 0.7147, for CRP was 0.7356, and for the combined diagnosis was 0.8350 (p < 0.05).
Conclusions:
- S100A12 protein and CRP are significant independent risk factors for MVA following AMI in elderly patients.
- The combined assessment of S100A12 protein and CRP demonstrates superior diagnostic sensitivity and specificity for MVA prediction.
Objective:
To investigate the association of S100A12 protein and C-reactive protein (CRP) with the onset of malignant ventricular arrhythmias (MVA) after acute myocardial infarction (AMI) in the elderly.
Methods:
A total of 159 elderly AMI patients admitted to Chongming Hospital affiliated to Shanghai University of Medicine & Health Sciences from January 2018 to January 2023 were enrolled in the study. CRP levels were determined using an automatic biochemical analyzer, and S100A12 levels were measured using enzyme-linked immunosorbent assay (ELISA). Patients were categorized based on the Lown classification into groups without MVA and with MVA. Univariate analysis was initially performed to identify independent variables, followed by multivariate logistic regression to determine the risk factors for malignant ventricular arrhythmias post-AMI. The predictive value of S100A12 protein and CRP for malignant ventricular arrhythmias after acute myocardial infarction in the elderly was analyzed using the receiver operating characteristic (ROC) curve.
Results:
Among the 159 patients with AMI, 27 (17%) had MVA. Multivariate logistic regression analysis indicated that both S100A12 protein and CRP could be independent risk factors for malignant ventricular arrhythmias following acute myocardial infarction in the elderly (p < 0.05). The area under the ROC curve showed the area under the curve (AUC) for S100A12 protein to be 0.7147, for CRP 0.7356, and for the combined diagnosis 0.8350 (p < 0.05).
Conclusion:
S100A12 protein and CRP are independent risk factors for MVA after MI in the elderly. The combined application of S100A12 protein and CRP has higher diagnostic sensitivity and specificity.
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