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Psychiatric Level 1A evidence pharmacogenomics in a Brazilian admixed cohort and global populations
Helena Pereira Ribeiro1, Beatriz Meza Baraldi1, Fernanda Rodrigues-Soares2
1Department of Morphology & Basic Pathology - Medical School, Faculdade de Medicina de Jundiaí, Jundiaí, 13202-550, Brazil.
Abstract:
Purpose: To compare minor allele frequencies (MAFs) of psychiatric drug response variants in a Brazilian admixed cohort with global populations and other Brazilian groups. Methods: PharmGKB MAFs were gathered from publicly available genetic datasets for Brazil and worldwide. Results: Among 146 variants in CYP2D6 and CYP2C19, 41 were present in Brazil, mostly rare (MAF <1%). 11 variants showed significant MAF differences with large effect sizes compared with global populations. CYP2C19*3 (rs4986893), CYP2C19*17 (rs12248560), CYP2D6*17 (rs28371706-A) and CYP2D6*29 (rs61736512) exhibited higher frequencies in Brazil, with the latter three also differing from other Brazilian groups. Conclusion: This study highlights significant pharmacogenomic diversity in Brazil and globally, underscoring the need for more research in personalized psychiatric drug therapy.
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