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Updated: Jun 30, 2026

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Dynamic Antimicrobial Poly(disulfide) Coatings Exfoliate Biofilms On Demand Via Triggered Depolymerization.

Yang Lou¹, Edmund F Palermo^1,2

¹Materials Science and Engineering, Rensselaer Polytechnic Institute, 110 8th St., Troy, NY, 12180, USA.

Advanced Healthcare Materials

|January 30, 2024

Summary

This study presents a novel antimicrobial coating that kills bacteria on contact. The coating can be mechanically delaminated on demand using UV light, offering a reusable solution for biofilm control.

Keywords:

antimicrobial biofilm depolymerization lipoic acid polymer

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Last Updated: Jun 30, 2026

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Assessing Biofilm Dispersal in Murine Wounds

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Published on: August 7, 2021

Area of Science:

Materials Science
Biotechnology
Surface Chemistry

Background:

Bacterial biofilms pose significant challenges in biomedical and industrial applications.
Current antimicrobial coatings lose efficacy over time due to fouling and require harsh cleaning methods.

Purpose of the Study:

To develop a dynamically reversible antimicrobial surface coating with on-demand biofilm removal capabilities.
To create a coating that combines contact-killing antimicrobial activity with triggered mechanical delamination.

Main Methods:

Synthesized antimicrobial polymer derivatives based on alpha-lipoic acid (LA) and quaternary ammonium salt groups.
Investigated dynamic and reversible polymerization into polydisulfides.
Evaluated coating performance against Staphylococcus aureus under varying microbial challenges.
Assessed biofilm removal via UV-triggered depolymerization.

Main Results:

Coatings demonstrated >99.9% killing of Staphylococcus aureus over 15 cycles for moderate challenges.
Fouling occurred under intense microbial challenges after 5 days.
UV-triggered degradation in aqueous solution at neutral pH successfully exfoliated attached biofilms.

Conclusions:

Developed a simple strategy for antimicrobial coatings with sustained contact-killing activity.
Achieved on-demand mechanical delamination of biofilms under mild conditions.
Offers a promising approach for long-term biofilm management in various applications.