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Industry involvement in rheumatology consensus-based recommendations: a systematic review.
Dominique Feterman Jimenez1, Garret Duron2, Joshua Hendin3
1UConn Health Center, Farmington, CT, USA.
The Lancet. Rheumatology
|January 30, 2024
Summary
Pharmaceutical industry sponsorship of rheumatology guidelines is common and often linked to lower quality recommendations. Professional society endorsement is associated with higher quality consensus-based clinical practice standards.
Area of Science:
- Rheumatology
- Clinical Practice Guidelines
- Pharmaceutical Industry Influence
Background:
- Consensus-based recommendations are crucial for establishing clinical practice standards.
- Potential for bias exists when pharmaceutical industry influences guideline development.
- Assessing the quality and objectivity of industry-sponsored guidelines is essential.
Purpose of the Study:
- To systematically review rheumatology consensus-based recommendations published between 2000-2020.
- To compare the quality of guidelines endorsed by professional societies versus those sponsored by the pharmaceutical industry.
- To evaluate the extent of industry involvement in the development of sponsored recommendations.
Main Methods:
- Systematic review of English-language rheumatology consensus-based recommendations (2000-2020).
- Utilized the Appraisal of Guidelines for Research & Evaluation (AGREE) II instrument for quality assessment.
- Compared guidelines endorsed by major professional societies against industry-sponsored guidelines.
Main Results:
- Of 234 recommendations, 51% were society-endorsed and 74% were industry-sponsored.
- Industry involvement included process participation (28%), medical writers (16%), honoraria (7%), and final draft approval (1%).
- Industry-sponsored projects demonstrated significantly lower quality scores on the AGREE II instrument compared to society-endorsed projects.
Conclusions:
- Industry sponsorship of rheumatology consensus-based recommendations is prevalent, particularly for those lacking professional society endorsement.
- Industry-sponsored guidelines are frequently of lower quality than those endorsed by major professional societies.
- Medical journals should implement measures to enhance guideline rigor and mitigate undue industry influence.
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