Related Experiment Video
Updated: Jul 4, 2025

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
Published on: June 28, 2021
IL15 and IL21: Better When Membrane-Tethered Together on Antitumor T Cells
Ayana T Ruffin1,2, Megen C Wittling1,2, Anna C Cole1,2
1Department of Surgery, Emory University, Atlanta, Georgia.
Abstract:
Systemic administration of homeostatic γ-chain cytokines mediates antitumor responses in some patients treated with adoptive immunotherapy. Yet many patients experience toxic side effects. New work presented herein suggests these limitations can be overcome by membrane-tethering IL15 and IL21 to T-cell products. This finding has major implications in advancing medicine. See related article by Nguyen et al., p. 1555.
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