Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonsecretory multiple myeloma.

D Rubio-Felix, M Giralt, M P Giraldo

    Cancer
    |May 15, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Subacute convexity subdural hematoma in a child with malignant Tourette syndrome: a case report.

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
    Same author

    Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor: Prospective Single-Centre Cohort and Systematic Review With Meta-Analysis.

    European journal of neurology·2026
    Same author

    Extradural hematoma management: A case-control study with historical controls reassessing the 'zero mortality' goal.

    Brain & spine·2026
    Same author

    Unilateral change of laryngeal adductor reflex and hiccups resolution after removal of bulbar hemangioblastoma: is there a connection?

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2025
    Same author

    Accelerator based-BNCT facilities worldwide and an update of the Buenos Aires project.

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2025
    Same author

    Knowledge, interest and perspectives on Artificial Intelligence in Neurosurgery. A global survey.

    Brain & spine·2025
    Same journal

    Real-world effectiveness of chemotherapy regimens after immunotherapy in patients with advanced melanoma in Spain: Results from the GEM1801 study.

    Cancer·2026
    Same journal

    Bendamustine in indolent lymphoma: Letting the dust settle down.

    Cancer·2026
    Same journal

    Top advances of the year: Bispecific antibodies in early lines of therapy in multiple myeloma.

    Cancer·2026
    Same journal

    Direct oral anticoagulants and warfarin in atrial fibrillation patients with cancer by anticoagulation quality.

    Cancer·2026
    Same journal

    Sexual orientation and gender identity based disparities in colorectal, cervical, and breast cancer screening in the United States.

    Cancer·2026
    Same journal

    Toward exercise as standard care for older cancer survivors.

    Cancer·2026
    See all related articles

    Multiple myeloma without M-component, a rare subtype, presents similarly to secretory multiple myeloma (MM). This study found comparable prognoses, challenging previous notions of an unfavorable outlook for this specific MM variant.

    Area of Science:

    • Hematology
    • Oncology

    Background:

    • Multiple myeloma (MM) is a plasma cell malignancy.
    • MM without detectable M-component in serum or urine is a rare subtype.
    • Previous reports suggested a poorer prognosis for MM without M-component.

    Purpose of the Study:

    • To investigate the clinical characteristics and prognosis of multiple myeloma (MM) without M-component.
    • To compare the outcomes of MM without M-component to those with secretory MM.

    Main Methods:

    • Retrospective analysis of 186 multiple myeloma patients.
    • Identification of five cases of MM without M-component.
    • Clinical data review including bone marrow biopsy, skeletal imaging, and immunoglobulin levels.
    • Immunofluorescence and ultrastructural analysis of plasma cells.

    Related Experiment Videos

  • Treatment and survival data analysis.

    • Main Results:

    • All five patients with MM without M-component had bone marrow plasmacytosis >30%.
    • Skeletal involvement (lytic lesions, osteoporosis, fractures) was common.
    • Striking hypogammaglobulinemia and reduced polyclonal immunoglobulins were observed.
    • Monoclonal light chains were detected in plasma cells of four patients.
    • Prognosis in this series was comparable to secretory multiple myeloma.

    Conclusions:

    • Multiple myeloma without M-component exhibits distinct immunophenotypic and biochemical features.
    • Despite prior beliefs, the prognosis for MM without M-component appears similar to secretory MM.
    • Further research is warranted to fully understand this rare MM variant.