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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

78
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

64
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
64
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

101
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
101
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

40
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Related Experiment Video

Updated: Sep 20, 2025

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
08:25

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

Published on: June 10, 2025

216

Risk factors for renal dysfunction after isolated intestinal transplantation.

Dagny von Ahrens1, Andrew D Santeusanio1,2, Alan D Weinberg3

  • 1Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.

Clinical Transplantation
|January 30, 2024
PubMed
Summary
This summary is machine-generated.

Kidney dysfunction is common after intestinal transplants. Patient age and stoma duration significantly impact kidney function decline one year post-transplant, highlighting the need for careful stoma management.

Keywords:
chronic kidney diseasedrug monitoringileostomyintestinal transplantationtacrolimus

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Area of Science:

  • Nephrology
  • Transplantation Surgery
  • Gastroenterology

Background:

  • Kidney dysfunction is a recognized complication of intestinal transplantation.
  • The precise incidence and risk factors for developing chronic kidney disease (CKD) post-intestinal transplant are not well-established.

Purpose of the Study:

  • To investigate the rate of kidney function decline and identify risk factors for chronic kidney disease (CKD) in adult intestinal allograft recipients.

Main Methods:

  • A retrospective review of 33 adult intestinal allograft recipients (2011-2019) was conducted.
  • Estimated glomerular filtration rate (eGFR) was assessed at 0, 6, and 12 months post-transplant.
  • Multivariable linear regression identified factors associated with eGFR decline at 1 year, including age, BMI, stoma duration, and vasopressor use.

Main Results:

  • A mean 42.3% decline in eGFR was observed at 1-year post-transplant.
  • 15.2% of patients developed new stage 4/5 CKD within the first year.
  • Increased patient age and longer stoma duration were significantly associated with a greater decline in eGFR at 1 year.

Conclusions:

  • Renal dysfunction is a frequent outcome following intestinal transplantation.
  • Careful consideration of stoma creation and timely reversal, when feasible, is recommended to protect renal function.