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Updated: Sep 20, 2025
08:25
A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
Published on: June 10, 2025
216
Risk factors for renal dysfunction after isolated intestinal transplantation
Dagny von Ahrens1, Andrew D Santeusanio1,2, Alan D Weinberg3
1Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.
Clinical Transplantation
|January 30, 2024
Summary
Kidney dysfunction is common after intestinal transplants. Patient age and stoma duration significantly impact kidney function decline one year post-transplant, highlighting the need for careful stoma management.
Area of Science:
- Nephrology
- Transplantation Surgery
- Gastroenterology
Background:
- Kidney dysfunction is a recognized complication of intestinal transplantation.
- The precise incidence and risk factors for developing chronic kidney disease (CKD) post-intestinal transplant are not well-established.
Purpose of the Study:
- To investigate the rate of kidney function decline and identify risk factors for chronic kidney disease (CKD) in adult intestinal allograft recipients.
Main Methods:
- A retrospective review of 33 adult intestinal allograft recipients (2011-2019) was conducted.
- Estimated glomerular filtration rate (eGFR) was assessed at 0, 6, and 12 months post-transplant.
- Multivariable linear regression identified factors associated with eGFR decline at 1 year, including age, BMI, stoma duration, and vasopressor use.
Main Results:
- A mean 42.3% decline in eGFR was observed at 1-year post-transplant.
- 15.2% of patients developed new stage 4/5 CKD within the first year.
- Increased patient age and longer stoma duration were significantly associated with a greater decline in eGFR at 1 year.
Conclusions:
- Renal dysfunction is a frequent outcome following intestinal transplantation.
- Careful consideration of stoma creation and timely reversal, when feasible, is recommended to protect renal function.
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