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Risk Profiling In Vitro Fertilization Pregnancies that Develop Placenta Accreta Spectrum
Anna M Modest1, Brett D Einerson2, Albaro J Nieto3
1Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
American Journal of Perinatology
|January 30, 2024
Summary
Pregnant individuals undergoing in vitro fertilization (IVF) with placenta accreta spectrum (PAS) have lower rates of antenatal suspicion for PAS. This may be due to fewer prior cesarean deliveries and less severe PAS in the IVF group.
Area of Science:
- Reproductive Medicine
- Maternal-Fetal Medicine
- Obstetrics
Background:
- Placenta accreta spectrum (PAS) is a significant obstetric complication.
- In vitro fertilization (IVF) is increasingly used for conception.
- Understanding risk factors and detection rates for PAS in IVF pregnancies is crucial.
Purpose of the Study:
- To compare antenatal suspicion rates of PAS between IVF and non-IVF pregnancies.
- To evaluate risk factors for PAS in IVF versus non-IVF patients.
- To assess the severity of PAS in relation to conception method.
Main Methods:
- International multicenter retrospective study (1998-2021).
- Included patients with pathologically confirmed PAS.
- Compared IVF pregnancies with non-IVF pregnancies using statistical tests.
Main Results:
- Antenatal PAS suspicion was less common in the IVF group (40.9%) compared to the non-IVF group (60.5%).
- IVF patients had lower rates of prior cesarean delivery and less severe PAS.
- The risk profile for PAS differs between IVF and non-IVF pregnancies.
Conclusions:
- Antenatal suspicion of PAS is lower in IVF pregnancies.
- This difference may be attributed to a lower incidence of prior cesarean deliveries and placenta previa, and less severe PAS in IVF patients.
- The risk profile for PAS is distinct in pregnancies conceived via IVF.
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