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Related Experiment Video

Updated: Jul 4, 2025

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
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The relationship between sensory processing sensitivity and medication sensitivity: brief report.

Jadzia Jagiellowicz1, Bianca P Acevedo2, Teresa Tillmann3

  • 1Department of Psychology, Stony Brook University, Stony Brook, NY, United States.

Frontiers in Psychology
|January 31, 2024
PubMed
Summary
This summary is machine-generated.

Individuals with sensory processing sensitivity (SPS) show increased sensitivity to medications. This trait, also known as being a highly sensitive person (HSP), impacts how people react to various stimuli and treatments.

Keywords:
adverse drug reactions (ADR)environmental sensitivitygendermedication adherencemedication sensitivitypersonalized and precision medicine (PPM)pharmacogenomicssensory processing sensitivity (SPS)

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Area of Science:

  • Psychology
  • Pharmacology
  • Neuroscience

Background:

  • Sensory processing sensitivity (SPS) is a heritable trait characterized by heightened awareness and reactivity to environmental stimuli.
  • Individuals with SPS may exhibit amplified responses to a wide range of stimuli, potentially including pharmacological agents.

Purpose of the Study:

  • To investigate the relationship between sensory processing sensitivity (SPS) and medication sensitivity.
  • To determine if SPS is a significant predictor of medication sensitivity, independent of negative affectivity and gender.

Main Methods:

  • Three studies were conducted with adult participants (N = 125, 214, 351) from university and online samples.
  • Participants completed self-report measures including a medication sensitivity scale, the highly sensitive person (HSP) scale for SPS, and a negative affectivity (NA) scale.
  • Statistical analyses examined correlations between SPS and medication sensitivity, controlling for NA and gender.

Main Results:

  • All three studies revealed moderate, significant positive correlations between SPS and medication sensitivity (r = 0.34, 0.21, 0.36).
  • These associations remained significant after controlling for negative affectivity and gender.
  • No significant interactions were found between SPS and gender regarding medication sensitivity.

Conclusions:

  • Sensory processing sensitivity (SPS) is significantly associated with medication sensitivity.
  • SPS should be considered in future research and clinical practice concerning medication recommendations, dosage, efficacy, and adverse drug reactions.
  • The findings highlight the importance of considering individual differences in sensory processing when evaluating medication responses.