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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
2.8K
Interactions between COVID-19 infection and diabetes.
1Endocrinology Metabolism Consulting, LLC, Hassan Heshmati and Valerie Shaw Endocrine Research, Anthem, AZ, United States.
Frontiers in Endocrinology
|January 31, 2024
Summary
The COVID-19 pandemic impacts diabetes through lifestyle changes and direct pancreatic effects. Diabetes also increases COVID-19 risk, highlighting bidirectional interactions.
Area of Science:
- Endocrinology
- Infectious Diseases
- Metabolic Disorders
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, has had global health and economic impacts.
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets cells via angiotensin-converting enzyme 2 (ACE2), which is present in endocrine glands.
- COVID-19 infection affects multiple endocrine and metabolic systems, including the endocrine pancreas.
Purpose of the Study:
- To examine the bidirectional relationship between the COVID-19 pandemic and diabetes.
- To understand how COVID-19 impacts the endocrine pancreas and diabetes development/exacerbation.
- To explore how diabetes influences COVID-19 infection risk and severity.
Main Methods:
- Review of existing literature on COVID-19, ACE2 expression, and endocrine pancreas function.
- Analysis of lifestyle changes during the pandemic (e.g., diet, physical activity) and their metabolic consequences.
- Examination of the role of cytokine storm in COVID-19-induced pancreatic dysfunction.
- Investigation of the impact of obesity and hyperglycemia on COVID-19 susceptibility and outcomes.
Main Results:
- COVID-19 pandemic can promote obesity and type 2 diabetes via lifestyle alterations.
- Direct impairment of the endocrine pancreas by COVID-19, potentially through cytokine storm, can promote or worsen type 1 and type 2 diabetes.
- Individuals with type 2 diabetes, characterized by increased ACE2 receptors and hyperglycemia, face higher risks of COVID-19 infection and severe outcomes.
- The immune system's response in diabetes can be negatively impacted, increasing COVID-19 morbidity and mortality.
Conclusions:
- There are significant bidirectional interactions between COVID-19 and diabetes.
- COVID-19 infection can negatively impact diabetes management and outcomes.
- Diabetes can increase the risk and severity of COVID-19 infection.
- Healthcare systems have adapted diabetes management services in response to the pandemic.
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