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Thymic lipofibroadenoma: A case report.

Arya Kazemi1, Amir Mohammad Nourizadeh2, Ghazal Arjmand1

  • 1Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Radiology Case Reports
|January 31, 2024
PubMed
Summary
This summary is machine-generated.

Lipofibroadenoma (LFA), a rare thymic epithelial tumor, was incidentally discovered in a 30-year-old female. Surgical excision confirmed LFA, highlighting its extreme rarity in females and the anterior mediastinum.

Keywords:
Case reportIncidental tumorsLipofibroadenomaPathologyThymus

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Area of Science:

  • Pathology
  • Thoracic Surgery
  • Oncology

Background:

  • Lipofibroadenoma (LFA) is a rare epithelial tumor typically found in the anterior mediastinum.
  • It is characterized by a coalescence of thymic epithelial, adipose, and fibrotic tissue.
  • Previously reported cases of thymic LFA have exclusively involved male patients.

Observation:

  • A 30-year-old female presented with an incidentally discovered left anterior superior mediastinal mass following a traffic accident.
  • Histologic examination of the surgically excised mass confirmed it as a lipofibroadenoma of the thymus.
  • The mass exhibited characteristic features of thymic parenchyma, including Hassall corpuscles, interspersed with fibro-adipose tissue.

Findings:

  • This case represents an extremely rare instance of thymic lipofibroadenoma in a female patient.
  • The tumor was a slow-growing, benign entity, consistent with known lipofibroadenoma characteristics.
  • Diagnosis was definitively established through histopathologic examination.

Implications:

  • The findings expand the known demographic profile of thymic lipofibroadenoma to include female patients.
  • Complete surgical excision (thymectomy) is the established treatment of choice for thymic lipofibroadenoma.
  • Accurate staging is crucial for determining the prognosis of thymic lipofibroadenoma.