Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

4.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
4.7K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.9K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.9K
Structural Protein Function01:56

Structural Protein Function

27.7K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
27.7K
Molecular Models02:00

Molecular Models

38.4K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
38.4K
Generation of Straight or Branched Actin Filaments01:14

Generation of Straight or Branched Actin Filaments

2.9K
The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
2.9K
Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

4.4K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The case for prospective MEN1 surveillance in the era of sequential menin inhibitor therapy.

Leukemia·2026
Same author

Brain shuttle peptides derived from phage display.

Advances in pharmacology (San Diego, Calif.)·2026
Same author

Premature termination of early-phase cancer clinical trials: "It's the economy, stupid!"

Journal of the National Cancer Institute·2026
Same author

Differential responses to sequential menin inhibitor therapy for acute leukemia underscore the complexities of acquired resistance.

Leukemia & lymphoma·2026
Same author

An emerging family of immunogenic epitopes in Chagas disease.

Trends in parasitology·2026
Same author

Decoding and deciphering a subcellular ZIP code system.

Trends in cell biology·2026
Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026
Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026
Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026
Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026
Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026
Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2025

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.7K

Generative artificial intelligence performs rudimentary structural biology modeling.

Alexander M Ille1,2,3, Christopher Markosian1,2,3, Stephen K Burley4,5,6,7

  • 1School of Graduate Studies, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.

Biorxiv : the Preprint Server for Biology
|January 31, 2024
PubMed
Summary
This summary is machine-generated.

Generative artificial intelligence (AI) can now perform basic structural biology modeling. GPT-4 demonstrated potential in predicting 3D structures and analyzing molecular interactions, showing promise for scientific research.

More Related Videos

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.1K
A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

68.7K

Related Experiment Videos

Last Updated: Jul 4, 2025

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.7K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.1K
A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

68.7K

Area of Science:

  • Structural biology
  • Computational chemistry
  • Artificial intelligence in science

Background:

  • Generative pre-trained transformer (GPT) models are increasingly used in scientific research.
  • Recent findings suggest GPT capabilities extend beyond natural language processing.
  • Exploring GPT-4's potential in structural biology modeling is a novel research area.

Approach:

  • GPT-4 was prompted to model 3D structures of 20 standard amino acids and an alpha-helical polypeptide chain.
  • Wolfram mathematical computation was integrated for polypeptide chain modeling.
  • Structural interaction analysis was performed between nirmatrelvir and the SARS-CoV-2 main protease.

Key Points:

  • Generated 3D structures showed geometric parameters approximating experimental references.
  • GPT-4 identified specific amino acid residues and bond distances in ligand-protein interactions.
  • Modeling accuracy was observed at an atomic scale, despite occasional errors with complex molecules.

Conclusions:

  • Natural language generative AI, specifically GPT-4, can perform rudimentary structural biology modeling.
  • GPT-4 shows capacity for basic structural interaction analysis, including identifying binding residues and distances.
  • While limitations exist, this demonstrates AI's potential to contribute to structural biology research.