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FISH - Fluorescent In-situ Hybridization

FISH - Fluorescent In-situ Hybridization

Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...

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Updated: Jul 4, 2025

Robust 3D DNA FISH Using Directly Labeled Probes

Robust 3D DNA FISH Using Directly Labeled Probes

Published on: August 15, 2013

SnapFISH-IMPUTE: an imputation method for multiplexed DNA FISH data.

Hongyu Yu^1,2, Daiqing Wu³, Guning Shen^4,5

¹Department of Statistics, University of Wisconsin-Madison, Madison, WI, USA.

Biorxiv : the Preprint Server for Biology

|January 31, 2024

Summary

This summary is machine-generated.

We developed SnapFISH-IMPUTE to fill in missing data from multiplexed DNA FISH, improving chromatin conformation analysis. This method accurately imputes missing values, enhancing downstream biological insights.

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Last Updated: Jul 4, 2025

Robust 3D DNA FISH Using Directly Labeled Probes

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Published on: August 15, 2013

Single Cell Analysis Of Transcriptionally Active Alleles By Single Molecule FISH

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Published on: September 20, 2020

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

Chromatin spatial organization is vital for gene regulation.
Multiplexed DNA FISH visualizes nuclear chromatin conformation.
Incomplete data from FISH limits downstream analysis.

Conclusions:

SnapFISH-IMPUTE effectively addresses data incompleteness in multiplexed DNA FISH.
The method enhances the reliability and resolution of chromatin conformation studies.
SnapFISH-IMPUTE is a valuable tool for advancing gene regulation research.