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Structural basis of respiratory complexes adaptation to cold temperatures
Biorxiv : the Preprint Server for Biology
|January 31, 2024
Summary
Mammals activate brown fat for thermogenesis in cold. This study reveals the cold-induced structural changes in respiratory supercomplexes, enhancing energy production.
Area of Science:
- Biochemistry
- Structural Biology
- Mammalian Physiology
Background:
- Mammals utilize brown fat thermogenesis for cold adaptation, a process dependent on the electron transport chain.
- The structural mechanisms underlying respiratory complex adaptation to cold temperatures are not well understood.
Conclusions:
- The study unveils the structural and energetic mechanisms of respiratory adaptation to cold.
- Cold exposure induces specific conformational changes in respiratory supercomplexes to optimize thermogenesis.
- Lipid-protein dynamics play a crucial role in stabilizing these adaptations for enhanced energy production.
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