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Venous Thromboembolism and Associated Factors in Hospitalized Patients with COVID-19 at Addis Ababa COVID-19 Field

Abel Teklit Haile1,2, Robel Gemechu Haile1,2,3, Esrom Hagos Gebrehiwot1,2,3

  • 1Research Department, Saint Peter Specialized Hospital, Addis Ababa, Ethiopia.

Infection and Drug Resistance
|January 31, 2024
PubMed

Insights

COVID-19 patients face increased risks of venous thromboembolism (VTE). Factors like severe illness, diabetes, hypertension, and prior VTE risk significantly elevate this danger, highlighting the need for vigilant monitoring and anticoagulation strategies.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Hematology

Background:

  • COVID-19 has been linked to an increased incidence of thrombotic events.
  • Emerging evidence suggests a predisposition to venous thromboembolism (VTE) in individuals infected with SARS-CoV-2.
  • This study investigated VTE and its associated factors in COVID-19 patients at a field hospital in Addis Ababa.

Purpose of the Study:

  • To identify factors associated with the development of thromboembolism in patients diagnosed with COVID-19.
  • To assess the risks and contributing elements for VTE in hospitalized COVID-19 patients.

Main Methods:

  • An institution-based case-control study was conducted.
  • Data analysis involved SPSS version 26 and multivariable binary logistic regression.

Main Results:

  • Severe COVID-19 cases (AOR=0.38) showed a reduced association with VTE, while pre-existing VTE risk factors (AOR=2.57) increased it.
  • Diabetes (AOR=3.745), chest pain (AOR=4.13), stage 1 hypertension (AOR=3.67), and hospital anticoagulation (AOR=11.78) were significantly associated with VTE development.
  • The odds of VTE were substantially higher in patients receiving hospital anticoagulation.

Conclusions:

  • A direct association exists between severe COVID-19 and factors including diabetes, pre-existing VTE risk, hypertension, and hospital anticoagulation.
  • These findings underscore the complex interplay between COVID-19 severity, comorbidities, and thrombotic risk.
  • Effective management strategies for VTE in COVID-19 patients are crucial.
Abstract

Keywords:
Addis AbabaCOVID-19Ethiopiacase controllogistic regressionvenous thromboembolism

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