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Related Experiment Videos

Spontaneous morphologic changes in left ventricular thrombi: a prospective two-dimensional echocardiographic study.

S Domenicucci, P Bellotti, F Chiarella

    Circulation
    |April 1, 1987
    PubMed
    Summary

    This study prospectively tracked left ventricular thrombi in myocardial infarction patients. Thrombi shape and mobility changed over time, indicating dynamic embolic potential in acute anterior myocardial infarction survivors.

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    Area of Science:

    • Cardiology
    • Medical Imaging

    Background:

    • Retrospective studies suggest protruding and mobile left ventricular thrombi (LVT) have higher embolic potential.
    • Understanding LVT dynamics is crucial for assessing embolic risk after myocardial infarction.

    Purpose of the Study:

    • To prospectively evaluate the shape and mobility of left ventricular thrombi.
    • To observe spontaneous changes in LVT characteristics over time in acute myocardial infarction patients.
    • To investigate the relationship between LVT dynamics and embolic potential.

    Main Methods:

    • Prospective echocardiographic assessment in 109 acute anterior myocardial infarction patients.
    • Serial imaging performed within 24 hours of symptom onset, with follow-up at 24-hour intervals until day 5, then 48-hour intervals until day 15, and monthly thereafter.

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  • No anticoagulant or antiplatelet therapy administered during the study period.

    • Main Results:

    • Left ventricular thrombi were detected in 59% of patients, appearing days to months after myocardial infarction.
    • At initial detection, thrombi were predominantly protruding (38 patients) rather than mural (21 patients).
    • Significant changes in thrombus shape (mural to protruding and vice versa) occurred in 41% of patients during follow-up, with mobility patterns resolving in most cases.

    Conclusions:

    • Left ventricular thrombi exhibit dynamic changes in shape and mobility after acute myocardial infarction.
    • These spontaneous variations may influence the embolic risk associated with LVT.
    • Prospective echocardiographic monitoring is essential for characterizing LVT evolution and potential embolic events.