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Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
Current status and future of cancer vaccines: A bibliographic study
Rui Yu1, Fangmin Zhao1, Zeting Xu1
1The First School of Clinical Medical, Zhejiang Chinese Medical University, Hangzhou, China.
Background:
Cancer vaccines are an important component of tumour immunotherapy. An increasing number of studies have shown that cancer vaccines have considerable clinical benefits. With the development of tumour precision medicine, cancer vaccines have become important because of their individualised targeting effects. However, few bibliometric studies have conducted comprehensive systematic reviews in this field. This study aimed to assess the scientific output and trends in cancer vaccine research from a global perspective.
Methods:
We collected publications on cancer vaccines from the Web of Science Core Collection database, which was limited to articles and reviews in English. Microsoft Excel, VOS Viewer, and CiteSpace V were used for quantitative and visual analyses.
Results:
A total of 7807 articles were included. From 1991 to 2022, the number of publications increased annually. The United States had the highest number of articles published in this field (48.28 %), the highest citation frequency (183,964 times), and the highest H-index (182). The National Institutes of Health topped the list with 476 articles. Schlom J had the highest number of published articles (128) and was the main investigator in this field. The journal, Cancer Immunology Immunotherapy, had published the highest number of articles in related fields. In recent years, tumour microenvironment, immune checkpoint inhibitors, particle vaccines, tumour antigens, and dendritic cells have become research hotspots related to cancer vaccines.
Conclusion:
Cancer vaccines are a popular research topic in the field of tumour immunotherapy. Related research and publications will enter a boom stage. "Immune checkpoint inhibitors", "tumour microenvironment" and "dendritic cells" may become future research hotspots, while "T-cell suppressor" is a potential puzzle to be solved.
Insights
Cancer vaccines are a growing area in tumor immunotherapy, with research rapidly expanding. Future research may focus on immune checkpoint inhibitors and the tumor microenvironment.
Area of Science:
- Immunology
- Oncology
- Biotechnology
Background:
- Cancer vaccines are crucial for tumor immunotherapy, offering significant clinical benefits.
- Precision medicine advances highlight the importance of individualized cancer vaccine targeting.
- A comprehensive bibliometric review of global cancer vaccine research trends was lacking.
Purpose of the Study:
- To conduct a bibliometric analysis of global cancer vaccine research.
- To identify scientific output, trends, and emerging hotspots in the field.
Main Methods:
- Publications on cancer vaccines were retrieved from the Web of Science Core Collection.
- Quantitative and visual analyses were performed using Microsoft Excel, VOS Viewer, and CiteSpace V.
- Data included articles and reviews published in English from 1991 to 2022.
Main Results:
- A total of 7,807 articles were published between 1991 and 2022, showing annual growth.
- The United States led in publications, citations, and H-index, with the National Institutes of Health as a leading institution.
- Key research hotspots include tumor microenvironment, immune checkpoint inhibitors, particle vaccines, tumor antigens, and dendritic cells.
Conclusions:
- Cancer vaccines represent a significant and expanding research area within tumor immunotherapy.
- Future research is likely to focus on immune checkpoint inhibitors, tumor microenvironment, and dendritic cells.
- Overcoming T-cell suppression remains a critical challenge in cancer vaccine development.
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