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Preventive effect of human umbilical cord mesenchymal stem cells on skin aging in rats

Juan Xiong1,2, Fan Wang1, Yutong Yang1

  • 1Department of Plastic and Burns, The Affiliated Hospital of Guizhou Medical University, China.

Heliyon
|January 31, 2024
PubMed

Insights

Human umbilical cord mesenchymal stem cells (hUCMSC) show promise in preventing skin aging. This study found hUCMSC intervention improved skin health markers in rats, suggesting potential anti-aging benefits.

Area of Science:

  • Dermatology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Skin aging is an irreversible process, driving significant medical research into anti-aging strategies.
  • Mesenchymal stem cells, particularly those derived from adipose tissue, are explored for their anti-aging potential in skin.
  • Human umbilical cord mesenchymal stem cells (hUCMSC) offer a viable alternative for skin anti-aging research.

Purpose of the Study:

  • To investigate the efficacy of human umbilical cord mesenchymal stem cells (hUCMSC) in preventing and reversing skin aging.
  • To evaluate the impact of hUCMSC intervention on key biomarkers and structural components of aged rat skin.

Main Methods:

  • A skin aging model was established in rats.
  • Intervention with human umbilical cord mesenchymal stem cells (hUCMSC) was performed on the aging rat model.
  • Analysis of rat skin and serum was conducted to assess changes in various biological markers and tissue characteristics.

Main Results:

  • hUCMSC intervention led to increased levels of EGF and VEGF in rat serum and skin.
  • A decrease in MDA content was observed, indicating reduced oxidative stress.
  • Skin thickness and dermal vessel count increased, alongside elevated Type I and Type III collagen mRNA expression.
  • MMP-1 content was significantly reduced post-hUCMSC treatment.

Conclusions:

  • Human umbilical cord mesenchymal stem cells (hUCMSC) demonstrate significant potential in preventing skin aging.
  • hUCMSC therapy positively influences skin structure, collagen synthesis, and reduces matrix degradation.
  • These findings support hUCMSC as a therapeutic agent for combating skin aging.
Keywords:
Anti-agingHuman umbilical cord mesenchymal stem cellsMesenchymal stem cellsSkin agingStem cell anti-aging

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