Related Experiment Video
Updated: Jul 4, 2025
07:06
Pentylenetetrazole-Induced Kindling Mouse Model
Published on: June 12, 2018
33.1K
Ketamine: Pro or antiepileptic agent? A systematic review
Islam Mohammad Shehata1, Neveen A Kohaf2, Mohamed W ElSayed3
1Ain Shams University, Cairo, Egypt.
Heliyon
|January 31, 2024
Summary
This review examines ketamine's safety in anesthesia, particularly its epilepsy risk. Evidence suggests ketamine is generally safe, with some data even supporting its use as an antiepileptic agent.
Area of Science:
- Anesthesiology
- Neurology
- Pharmacology
Background:
- Ketamine, a dissociative anesthetic, is explored for epilepsy treatment.
- Conflicting data exists on ketamine's pro-epileptic potential, confusing anesthesiologists.
- Case reports suggesting pro-epileptic properties often involve specific contexts, like single-agent procedural sedation.
Purpose of the Study:
- To systematically review the safety of ketamine concerning its potential to provoke epilepsy.
- To provide guidance for anesthesiologists regarding ketamine use in patients with or at risk of epilepsy.
Main Methods:
- Evidence-based systematic review of existing literature.
- Analysis of studies reporting on ketamine's effects on seizure activity.
Main Results:
- Conflicting literature exists regarding ketamine's pro-epileptic properties.
- Retrospective analyses indicate a potential antiepileptic role for ketamine.
- No contraindications for ketamine use in epileptic patients were identified, though combination with other agents may improve safety.
Conclusions:
- Ketamine appears generally safe regarding epilepsy provocation.
- Further research supports ketamine's potential as an antiepileptic agent.
- Careful patient selection and co-administration with agents like benzodiazepines or propofol can enhance safety in specific scenarios.
More Related Videos
Related Concept Videos
01:20Antiepileptic Drugs: Potassium Channel Activators
183
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
183
01:14Antiepileptic Drugs: Glutamate Antagonists
359
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
359
01:18Antiepileptic Drugs: GABAergic Pathway Potentiators
403
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
403
01:17Antiepileptic Drugs: Calcium Channel Blockers
403
Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
403
01:24Arteries of the Lower Limbs
190
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
190
01:08Antiepileptic Drugs: Sodium Channel Blockers
567
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
567