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Visible-light Induced Reduction of Graphene Oxide Using Plasmonic Nanoparticle
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Graphene Quantum Dots: Green Synthesis, Characterization, and Antioxidant and Antimicrobial Potential
Pooja Kadyan1, Ponnusamy Thillai Arasu2, Sudhir Kumar Kataria1
1Department of Zoology, Maharshi Dayanand University, Rohtak, Haryana, India.
International Journal of Biomaterials
|January 31, 2024
Summary
Green synthesis of graphene quantum dots (GQDs) from M. indica leaves shows potent antioxidant and antibacterial activity. These novel GQDs offer an efficient alternative for combating antibiotic-resistant microorganisms.
Area of Science:
- Materials Science
- Nanotechnology
- Biotechnology
Background:
- Antibiotic resistance is a growing global health concern, necessitating the development of new antimicrobial agents.
- Novel nanomaterials offer potential solutions due to their unique properties and enhanced biological efficacy.
Purpose of the Study:
- To synthesize graphene quantum dots (GQDs) using a green chemistry approach with M. indica leaves.
- To evaluate the antioxidant and antimicrobial properties of the synthesized GQDs.
Main Methods:
- Green synthesis of GQDs using M. indica leaf extract.
- Characterization using FTIR, XRD, SEM, TEM, and UV-Vis spectroscopy.
- In vitro antioxidant assays (scavenging efficacy, IC50) and antimicrobial susceptibility testing against bacteria and fungi.
Main Results:
- Spherical GQDs were successfully synthesized and characterized.
- Synthesized GQDs demonstrated superior antioxidant activity compared to the ethanolic leaf extract, indicated by a lower IC50 value.
- GQDs exhibited significant broad-spectrum antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and fungi (Aspergillus niger, Aspergillus flavus).
Conclusions:
- Green synthesized GQDs possess significant antioxidant and antimicrobial properties.
- The mechanism involves the facilitation of reactive oxygen species (ROS) generation.
- This study presents a sustainable and effective method for developing GQDs as a potential therapeutic agent against resistant microorganisms.
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