Related Experiment Video
Updated: Jul 4, 2025
Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
Fabrication, Characterization and Wound-Healing Properties of Core-Shell SF@chitosan/ZnO/Astragalus Arbusculinus Gum
Zahra Amiri1, Amir Mahdi Molavi2, Amir Amani3
1Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 74877-94149, Iran.
Aim:
Silk fibroin/chitosan/ZnO/Astragalus arbusculinus (Ast) gum fibrous scaffolds along with adipose-derived mesenchymal stem cells (ADSCs) were investigated for accelerating diabetic wound healing.
Methods:
Scaffolds with a core-shell structure and different compositions were synthesized using the electrospinning method. Biological in vitro investigations included antibacterial testing, cell viability analysis and cell attachment evaluation. In vivo experiments, including the chicken chorioallantoic membrane (CAM) test, were conducted to assess wound-healing efficacy and histopathological changes.
Results:
The incorporation of Ast to the silk fibroin@ chitosan/ZnO scaffold improved wound healing in diabetic mice. In addition, seeding of ADSCs on the scaffold accelerated wound healing.
Conclusion:
These findings suggest that the designed scaffold can be useful for skin regeneration applications.
