Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

3.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.6K
Telomeres and Telomerase02:41

Telomeres and Telomerase

23.3K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
23.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.

medRxiv : the preprint server for health sciences·2026
Same author

Explainability Challenges in Medical AI: The Conceptual Hidden Cost of Machine Learning Preprocessing.

Health science reports·2026
Same author

Understanding pre-training data effects in retinal foundation models using two large fundus cohorts.

Nature communications·2026
Same author

A computationally frugal, open-source chest CT foundation model for thoracic disease detection in lung cancer screening programmes.

Communications medicine·2026
Same author

Clinical Phenotypes in Hypertension: A Data-Driven Approach to Risk Stratification.

Hypertension (Dallas, Tex. : 1979)·2025
Same author

Integrative Genetic, Proteogenomic, and Multi-omics Analyses Reveal Sex-Biased Causal Genes and Drug Targets in Alzheimer's Disease.

medRxiv : the preprint server for health sciences·2025

Related Experiment Video

Updated: Jul 4, 2025

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

1.7K

Leukocyte Telomere Length and Cardiac Structure and Function: A Mendelian Randomization Study.

Ahmed M Salih1,2,3, Ilaria Boscolo Galazzo4, Gloria Menegaz4

  • 1William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London UK.

Journal of the American Heart Association
|January 31, 2024
PubMed
Summary
This summary is machine-generated.

Shorter leukocyte telomere length is causally linked to faster cardiac aging. This study found a significant association between telomere length and left ventricular mass, suggesting a role in cardiovascular aging.

Keywords:
Mendelian randomizationcardiac IDPstelomere

More Related Videos

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.5K
Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

23.1K

Related Experiment Videos

Last Updated: Jul 4, 2025

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

1.7K
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.5K
Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

23.1K

Area of Science:

  • Genetics
  • Cardiology
  • Aging Research

Background:

  • Shorter leukocyte telomere length is associated with age-related diseases, including cardiovascular disease.
  • The direct causality between telomere length and cardiovascular aging remains unclear.
  • Cardiac aging can be assessed using cardiac magnetic resonance imaging (CMR) phenotypes.

Purpose of the Study:

  • To investigate the causal relationship between leukocyte telomere length and cardiac aging.
  • To examine the association between telomere length and CMR-derived measures of cardiac structure and function.

Main Methods:

  • Utilized a 2-sample Mendelian randomization approach.
  • Assessed the causal link between genetically predicted leukocyte telomere length and 54 CMR measures.
  • Analyzed data across all four cardiac chambers.

Main Results:

  • Genetically predicted shorter leukocyte telomere length showed a causal association with reduced ventricular cavity sizes.
  • Significant links were observed with left ventricular end-systolic volume, left ventricular end-diastolic volume, and pulmonary artery measures.
  • A robust causal association was found between shorter telomere length and lower left ventricular mass (β=0.217, FDR P=0.016) after multiple testing correction.

Conclusions:

  • Findings support a causal role for shorter leukocyte telomere length in accelerating cardiac aging.
  • The most significant association was observed with left ventricular mass, highlighting its potential as a key indicator.