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Updated: Jul 4, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Progression and expansion of quinoline as bioactive moiety: a patent review
Yash Chauhan1, Kumari Neha1, Sharad Wakode1
1Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences & Research, Delhi Pharmaceutical Sciences & Research University, New Delhi.
Abstract:
Quinoline inhibitors are appealing medicinal products for a range of illnesses and problems. It is bicyclic heterocyclic scaffold has been intensively employed in pharmacological research and is well known for its wide range of biological purposes. Biological activities exhibited by quinoline derivatives, such as anti-inflammatory properties, antioxidant, antimicrobial, anti-tubercular, antidiabetic, anti-malarial and others are covered in detail in this review. The IC50 of patented inhibitors might range from nm to μM range, based on the experiments used. It presents an outline of patents file between 2002 and 2023 concerning to biological activities by quinoline derivatives. As a result, it is critical to develop additional chemical quinoline core alterations for novel chemical compounds and enhanced pharmacological impacts.
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