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Direct Injection Electrospray Ionization Mass Spectrometry (ESI-MS) Analysis of Proteins with High Matrix

Ruben Szabo1, Cynthia Nagy1, Attila Gaspar1

  • 1Department of Inorganic and Analytical Chemistry, Institute of Chemistry, University of Debrecen, Debrecen, 4032, Hungary.

Angewandte Chemie (International Ed. in English)
|January 31, 2024
PubMed
Summary

This study introduces Taylor-Aris dispersion-assisted mass spectrometry (TADA-MS) for direct analysis of therapeutic proteins. This method effectively resolves interference issues in complex samples without prior purification.

Keywords:
Taylor–Aris dispersioncapillary electrophoresismass spectrometrymonoclonal antibodyproteomics

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