Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A wearable biomechanical system for medical evaluation of soft tissue disorders.

Science advances·2026
Same author

Gut microbiota transfer from autoimmune dry eye mice imprints stereotypic B cell receptor repertoires in the lacrimal gland and induces disease.

Frontiers in immunology·2026
Same author

Case Report-Uterine Necrosis: A Rare Complication of Uterine Artery Embolization in Postpartum Hemorrhage.

Reports (MDPI)·2026
Same author

A biphasic astrocytic PTGDS trajectory marks a metabolic vulnerability stage in prodromal Alzheimer's disease.

Research square·2026
Same author

Enhanced Control of Pepper Anthracnose through Co-Application of Paenibacillus polymyxa GYUN-2285 and Pseudomonas protegens GYUN-2679.

The plant pathology journal·2026
Same author

Analysis of Clinical Characteristics and Treatment Efficacy in the Korean Hepatitis B Cohort.

Public health weekly report·2026

Related Experiment Video

Updated: Jun 23, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
13:37

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

18.2K

Synthesis and Structural Characterization of Macrocyclic α-ABpeptoids and Their DNA-Encoded Library.

Soobin Lee1, Hyunchul Kwon1, Eun-Kyoung Jee1

  • 1Department of Chemistry and Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea.

Organic Letters
|January 31, 2024
PubMed
Summary

Researchers synthesized novel macrocyclic alpha-aminobutyric acid (α-AB) peptoids. Structural analysis revealed unique chair-like and saddle-like conformations, paving the way for new molecular designs.

More Related Videos

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.9K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.3K

Related Experiment Videos

Last Updated: Jun 23, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
13:37

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

18.2K
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.9K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.3K

Area of Science:

  • Organic Chemistry
  • Supramolecular Chemistry
  • Structural Biology

Background:

  • Macrocyclic compounds offer unique structural and functional properties.
  • Peptoids, or peptidomimetics, are valuable in drug discovery due to their stability.
  • Understanding the conformational preferences of macrocyclic peptoids is crucial for their application.

Purpose of the Study:

  • To report the first synthesis of macrocyclic alpha-aminobutyric acid (α-AB) peptoids.
  • To elucidate the three-dimensional structures of these novel macrocycles.
  • To develop a method for generating diverse libraries of macrocyclic α-ABpeptoids.

Main Methods:

  • Synthesis of macrocyclic α-ABpeptoids with varying ring sizes.
  • X-ray crystallography for detailed structural analysis.
  • DNA-encoded combinatorial library synthesis.

Main Results:

  • Successful synthesis of macrocyclic α-ABpeptoids of diverse lengths.
  • X-ray structures revealed a chair-like conformation for the cyclic trimer with a cct amide sequence.
  • X-ray structures identified a saddle-like conformation for the cyclic tetramer with an uncommon cccc amide arrangement.

Conclusions:

  • The study presents the first synthesis and structural characterization of macrocyclic α-ABpeptoids.
  • The conformational diversity (chair-like and saddle-like) highlights the unique structural potential of these molecules.
  • The development of a DNA-encoded library enables rapid exploration of chemical space for this new class of compounds.