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Synthesis and Structural Characterization of Macrocyclic α-ABpeptoids and Their DNA-Encoded Library
Soobin Lee1, Hyunchul Kwon1, Eun-Kyoung Jee1
1Department of Chemistry and Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea.
Organic Letters
|January 31, 2024
Abstract:
The first synthesis of macrocyclic α-ABpeptoids with varying lengths is described. X-ray crystal structures reveal that cyclic trimer displays a chair-like conformation with a cct amide sequence and cyclic tetramer has a saddle-like structure with an uncommon cccc amide arrangement. The creation of a DNA-encoded combinatorial library of macrocyclic α-ABpeptoids is described.

