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Thermally programmable time delay switches for multi-step assays in paper-based microfluidics.

Saeed Atabakhsh1, Hossein Haji Abbasali2, Shahin Jafarabadi Ashtiani2

  • 1Department of Electrical Engineering, Roudehen Branch, Islamic Azad University, Roudehen, Iran.

Talanta
|January 31, 2024
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Summary

This study introduces a novel thermally programmable time-delay switch for paper-based microfluidic devices. This innovation enables controlled fluid delays, automating complex diagnostic assays for point-of-care applications.

Keywords:
Colorimetric detectionMulti-step assaysPaper-based microfluidcsResistive heatingThermal actuation

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Area of Science:

  • Microfluidics
  • Analytical Chemistry
  • Materials Science

Background:

  • Paper-based microfluidic devices (μPADs) are cost-effective for point-of-care diagnostics.
  • Controlling fluid actuation in complex, multi-step μPAD assays remains a significant challenge.

Purpose of the Study:

  • To develop a novel thermally programmable time-delay switch (TPTDS) for precise fluid control in μPADs.
  • To automate sequential reagent delivery in microfluidic diagnostic assays.

Main Methods:

  • Screen-printed wax micro-bridges were fabricated on μPADs.
  • An electrical power feedback loop controlled micro-bridge temperature, melting wax to create time delays.
  • The TPTDS was integrated into a nitrate assay, with colorimetric detection used for quantification.

Main Results:

  • The TPTDS successfully created programmable time delays by controlling wax penetration depth.
  • Automated sequential reagent delivery was achieved for the nitrate assay.
  • Colorimetric detection provided quantifiable results, demonstrating assay functionality.

Conclusions:

  • The TPTDS offers a robust method for fluid control in paper-based microfluidics.
  • This technology enhances the automation capabilities of μPADs for complex diagnostic applications.
  • The TPTDS is a promising advancement for point-of-care diagnostics.