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Animal obesities.

B Jeanrenaud

    Annales De La Nutrition Et De L'Alimentation
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Hyperinsulinemia drives obesity-related metabolic issues, including increased fat production and impaired insulin clearance in the liver. Correcting high insulin levels reverses these detrimental effects in obese animal models.

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    Area of Science:

    • Metabolic research
    • Obesity research
    • Endocrinology

    Background:

    • Genetically obese animals exhibit increased hepatic lipogenesis, hepatic lipoprotein secretion, and adipose tissue lipogenesis.
    • These metabolic abnormalities are closely linked to hyperinsulinemia, with normalization observed upon correction of high insulin levels.

    Purpose of the Study:

    • To investigate the role of hyperinsulinemia in the metabolic dysfunctions observed in obese animals.
    • To explore the relationship between hyperinsulinemia, hepatic insulin clearance, and insulin resistance in obesity.

    Main Methods:

    • Studied genetically obese animals (e.g., ob/ob mice) and experimentally induced obesity models.
    • Analyzed hepatic lipogenesis, hepatic lipoprotein secretion, adipose tissue lipogenesis, and hepatic insulin clearance.

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  • Evaluated the effects of correcting hyperinsulinemia on these metabolic parameters.

    • Main Results:

    • Obese animals displayed increased hepatic and adipose tissue lipogenesis and elevated hepatic lipoprotein secretion, all associated with hyperinsulinemia.
    • A significant defect in hepatic insulin clearance was observed in obese mice, which improved upon normalization of insulin levels.
    • The study demonstrated that hyperinsulinemia is a central factor in the metabolic abnormalities of obesity, including insulin resistance.

    Conclusions:

    • Hyperinsulinemia is a key feature of obesity syndromes, potentially causing most observed abnormalities, including insulin resistance.
    • Decreased hepatic insulin clearance in obese animals is linked to hyperinsulinemia and improves with insulin level normalization.
    • The underlying cause of hyperinsulinemia in genetically obese animals remains undetermined, with potential origins in pancreatic dysfunction or hypothalamic dysregulation.