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High-performance sulfonated polyether sulfone/chitosan membrane on creatinine transport improved by lithium chloride
Retno Ariadi Lusiana1, Rahmad Nuryanto1, Nailul Muna1
1Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, 50275 Semarang, Indonesia.
International Journal of Biological Macromolecules
|January 31, 2024
Summary
Modified polyethersulfone (PES) membranes with sulfonation, chitosan, and lithium chloride show improved hydrophilicity and enhanced creatinine transport for hemodialysis applications.
Area of Science:
- Materials Science
- Biomedical Engineering
- Chemical Engineering
Background:
- Polyethersulfone (PES) membranes possess desirable properties like mechanical strength and thermal stability for hemodialysis.
- The inherent hydrophobicity of PES membranes limits their efficiency in transporting creatinine, a key waste product removed during dialysis.
Purpose of the Study:
- To enhance the performance of PES membranes for hemodialysis by improving creatinine transport.
- To modify PES membranes through sulfonation and the incorporation of chitosan (CS) and lithium chloride (LiCl).
Main Methods:
- PES membranes were modified using a sulfonation process.
- Chitosan (CS) and lithium chloride (LiCl) were incorporated into the sulfonated PES membranes (SPES/CS-LiCl).
- Fourier-transform infrared (FTIR) spectroscopy was used to confirm the successful preparation of the modified membrane.
Main Results:
- FTIR analysis confirmed the presence of sulfonate, amine, and hydroxyl groups in the modified SPES/CS-LiCl membrane.
- The modified PES membranes exhibited increased porosity, swelling, water absorption, and hydrophilicity compared to pure PES.
- Creatinine clearance was significantly improved, rising from 0.30 mg/dL for pure PES to 0.42 mg/dL for the SPES/CS-LiCl (5:2) membrane.
Conclusions:
- The sulfonation of PES membranes combined with CS and LiCl effectively enhances hydrophilicity and porosity.
- The modified SPES/CS-LiCl membranes demonstrate superior performance in creatinine transport, making them promising for hemodialysis.
- This modification strategy offers a viable route to improve the efficacy of hemodialysis membranes.
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