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Five new secondary metabolites from Aster tataricus.

Jian-Li Li1, Chao Chen1, Min-Jie Ma1

  • 1Shanxi Modern Chinese Medicine Engineering Laboratory, Shanxi University of Chinese Medicine, Jinzhong 030619, China.

Fitoterapia
|January 31, 2024
PubMed
Summary

Five novel compounds, tatarisides A-E, were identified in Aster tataricus L.f. ethanol extract. Compounds 1 and 5 demonstrated significant anti-inflammatory activity by inhibiting nitric oxide release.

Keywords:
Anti-inflammatory activityAster tataricus L.f.MonoterpeneTerpenoidTriterpenoid

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology

Background:

  • Aster tataricus L.f. is recognized for its abundant bioactive constituents.
  • The chemical profile of A. tataricus L.f. remains incompletely characterized, particularly regarding novel compounds.

Purpose of the Study:

  • To identify and characterize previously unreported bioactive compounds from the ethanol extract of Aster tataricus L.f.
  • To evaluate the anti-inflammatory potential of isolated compounds.

Main Methods:

  • Extraction and isolation of compounds from Aster tataricus L.f. ethanol extract.
  • Structure elucidation using advanced spectroscopic techniques (NMR) and computational methods (ECD, NMR calculations).
  • In vitro anti-inflammatory assays using lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells to measure nitric oxide (NO) inhibition.

Main Results:

  • Five new compounds, designated tatarisides A-E (1-5), were successfully identified and structurally characterized.
  • Two known compounds (6, 7) were also isolated and identified.
  • Compounds 1 and 5 exhibited significant anti-inflammatory properties, effectively inhibiting NO release in LPS-stimulated RAW 264.7 cells with IC50 values of 17.81 ± 1.25 μM and 13.32 ± 0.84 μM, respectively.

Conclusions:

  • The study successfully identified novel compounds from Aster tataricus L.f., expanding the knowledge of its chemical diversity.
  • The findings highlight the potential of tatarisides A and E as lead compounds for developing new anti-inflammatory agents.